Computational Structural Biology

Welcome to the Künze Lab

Research in our lab is exploring the structural and dynamical properties of proteins using combined computational and experimental approaches. We develop and apply molecular modeling methods such as ROSETTA and molecular dynamics simulation with the following major goals in mind:

In-silico experiments are coupled with biophysical experiments, which we pursue in our laboratory or in collaboration with other scientists. Our experimental approaches rely on reporter group techniques (e.g., NMR and EPR spectroscopy), which help us to measure distances over several nanometers in proteins and capture the intricate structural flexibility of proteins.

Current applications focus on membrane protein receptors and ion channels, the design of plastic-degrading enzymes, and the use of NMR for characterizing protein-ligand interactions.

Please browse the menu for more information about our research.